Outwitting Evolution - Progress Towards Clinical Xenotransplantation
نویسندگان
چکیده
منابع مشابه
Progress towards clinical xenotransplantation.
Xenotransplantation has progressed from early heroic experiments on the path to meet the ever increasing demands of tissue and organ transplantation in patients with end-stage organ failure. The pig species is regarded as the most promising donor species. However, due to the evolutionary distance, innovative approaches are to be developed to permit life-supporting function in humans. Transplant...
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Two baboon liver xenografts transplanted to patients with B virus hepatitis supported life for 70 and 26 days but did not function optimally despite minimum or no histopathologic findings of overt humoral or cellular rejection in serial biopsies. However, there was evidence of complement activation in both cases, which in retrospect was thought to explain the unsatisfactory outcome. Strategies ...
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Xenotransplantation using pig cells, tissues or organs is considered to be a solution to the shortage of human allotransplants. Pigs have been selected as optimal donor for several reasons, among them physiological and economical. Before xenotransplantation will be applied broadly in the clinic three hurdles need to be overcome: (i) rejection due to immune reactions and coagulation dysfunction,...
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Microinjection of foreign DNA into pronuclei of a fertilized oocyte has predominantly been used for the generation of transgenic livestock. This technology works reliably, but is inefficient and results in random integration and variable expression patterns in the transgenic offspring. Nevertheless, remarkable achievements have been made with this technology with regard to xenotransplantation. ...
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Although caused by vastly different pathogens, the world's three most serious infectious diseases, tuberculosis, malaria, and HIV-1 infection, share the common problem of drug resistance. The pace of drug development has been very slow for tuberculosis and malaria and rapid for HIV-1. But for each disease, resistance to most drugs has appeared quickly after the introduction of the drug. Learnin...
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ژورنال
عنوان ژورنال: The Journal of Surgery
سال: 2003
ISSN: 1741-6280
DOI: 10.1016/s1743-9191(06)60003-4